Interrelationship of Prenatal and Postnatal Growth, Hormones, Diet and Breast Cancer
Abstract
The purpose of this Career Development Award was to expand Dr. Sanderson's current breast cancer research from the effect of intrauterine exposure to estrogen on breast cancer to the interrelationships of prenatal and postnatal growth, hormones, diet and breast cancer. Eased on these interrelationships, we hypothesized that insulin resistance will be positively associated with breast cancer. Further, we hypothesized that genetic susceptibility, and adolescent/adult diet and physical activity will modify the effect of insulin resistance on breast cancer. Specific aims were: 1) to undergo intensive training in cancer biology, and nutritional, molecular and genetic epidemiology, 2) to obtain funding to conduct case-control studies of the insulin resistance-breast cancer relationship, and 3) to obtain funding to conduct a cohort study of the association between prenatal and postnatal growth and infant hormone levels. During the second year of the study, Dr. Sanderson audited Introduction to Genetic and Molecular Epidemiology, conducted analyses of dietary intake and anthropometric measurements from the Shanghai Breast Cancer Study, submitted a preproposal for a HECUIMI Partnership Award to the Department of Defense to investigate insulin resistance and breast cancer, and participated in the Lower Rio Grande Valley Nutrition Intervention Research Initiative consortium.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2002
- Accession Number
- ADA406330
Entities
People
- Maureen Sanderson
Organizations
- University of South Carolina