Low Level Chemical Toxicity: Relevance to Chemical Agent Defense
Abstract
A multidisciplinary project is underway to study the influence of low-level exposure to chemicals to which military personnel had contact during the Persian Gulf War. The research group includes investigators with expertise in neuroscience, molecular biology, enzymology, cardiovascular physiology and neuropharmacology. The focus is on testing the effect of low doses of pyridostigmine bromide (PB), DEET, and Sarin with investigations of 1) effect of combined chemical and stress exposure on behavioral, cardiovascular, endocrine and cholinergic function 2) effect of stress and chemical exposure on auditory brain responses using electrophysiology, energy metabolism using nuclear magnetic resonance (NMR) techniques and mitochondrial function 3) activity of aldehyde and alcohol dehydrogenases and esterases in human samples with the goal of establishing whether there are alterations in populations characterized as chemically sensitive and 4) gene expression using a DNA microarray system to test the effect of chemical exposure on a neuronal cell line. The overall objective is to study the effect of chemical exposure from the single cell/gene level to the whole animal and ending with the human condition.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2002
- Accession Number
- ADA406512
Entities
People
- Mariana Morris
Organizations
- Wright State University