Pokeweed Antiviral Protein as an Universal Virus Neutralizer
Abstract
The objective of this project is to develop strategies which will allow the use of recombinant mutant pokeweed antiviral protein (PAP) as a potential countermeasure against biological warfare attempts employing pathogenic viruses. In order to increase the therapeutic index of the naturally occurring PAP, recombinant PAP mutants with superior antiviral activity and low toxicity will be constructed. The recombinant PAP mutants will be designed using the state-of-the-art technologies including X-ray crystallography, computer modeling, rational protein design and protein engineering.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2002
- Accession Number
- ADA406700
Entities
People
- Fatih M. Uckun