The Regulation of the Angiogenic Factor FGF-Binding Protein (FGF-BP) by the APC/beta-Catenin Signaling Pathway in the Progression of Breast Cancer
Abstract
Angiogenic vessel growth in solid tumors is crucial for the survival of the tumor and provides an avenue for the tumor cells to metastasize to distant sites. Breast cancer tumors are also dependent on angiogenesis for survival. Therefore, understanding the underlying mechanisms of the angiogenic process in breast cancer will enhance our knowledge of the carcinogenic process and provide potential therapeutic targets for the treatment of breast cancer. Our lab has previously shown that FGF-BPl. a binding protein for the angiogenic factor FGF-2, is overexpressed in a certain subset of breast cancers. in the current study we have found that FGF-BP1 is also overexpressed in the mammary tumors of the Min/+ mice, a mouse model that expresses high levels of the oncogene beta-catenin. Using in vitro assays we also show that FGF-BPl is a direct transcriptional target of beta-catenin that may be working through a novel l3bp fragment in the FGF-BPl promoter.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2002
- Accession Number
- ADA406733
Entities
People
- Ranjan Ray
Organizations
- Georgetown University