Coactivators and Corepressors in Breast Development and Receptor-Dependent Tumorigenesis
Abstract
Estrogens are important regulators of growth and differentiation in the normal mammary gland and are also important in the development and progression of breast carcinoma. Estrogens regulate gene expression via estrogen receptor (ER) and, because approximately two-thirds of all breast cancers are ER+ at the time of diagnosis, the expression of the receptor has important implications for their biology and therapy. ER binds to the estrogen response element (ERE) found in the promoters of estrogen- regulated genes and activates their transcription. Several ER-associated proteins, coactivators and corepressors, have been identified that are of importance in regulating the ER interaction with the basal transcription machinery. Between the coactivators, a group of proteins of approximately 160 KDa molecular mass were among the first factors identified that interact with nuclear receptors in a highly ligand-dependent manner. On the other hand, in the absence of ligand, several nuclear receptors suppress basal gene transcription by recruiting corepressors. Herein, we will address the role of the ER-associated proteins in ER action.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2002
- Accession Number
- ADA406847
Entities
People
- Ivan G. Bassets
- Soo-kyung Lee
Organizations
- University of California, San Diego