The Role of ROS in Breast Cancer Metastasis
Abstract
Certain human carcinoma cell lines produce reactive oxygen species (ROS) constitutively. This affords them potentially with an advantage in cell proliferation, and in migration and invasion of surrounding tissues by degrading the surrounding extracellular matrix and by increasing their motility. The basis for generation or upregulation of ROS in cancer cells is so far unllnown. We hypothesized that recently identified, novel ROS-producing enzyme systems may be involved in this phenomenon and proposed to define members of this family in breast cancer cells and to evaluate their role in events leading to metastasis.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2002
- Accession Number
- ADA406881
Entities
People
- Ulla G. Knaus
Organizations
- Scripps Research