Low Vision Research at the Schepens Eye Research Institute
Abstract
This research proposal, Low Vision at the Schepens Eye Research Institute, is a multi-disciplinary effort aimed at advancements in low vision research. Project 1, which focuses on dry eye complications of LASIK surgery, is in progress, having been delayed by the IRB process. Work on Project 2, ocular injury and inflammation, which has studied the role of FasL in corneal inflammation, has demonstrated that soluble FasL can block corneal inflammation induced by endotoxin. Project 3, which studies restoration of endothelial function of the damaged cornea, has assessed a variety of temperature sensitive polymers and growth factor for cornea endothelial cell growth. Project 4, which focuses on remote diagnosis of retinal damage, has obtained proof of principle for the optical plan for a portable prototype instrument to image retina for potential damage. Project 5, which studies regeneration of the damaged central nervous system, has defined the mechanism of lithium effects on retinal ganglion cell axon regeneration via Bc 1-2 induction. Project 6, regulation of angiogenesis and the role of VEGF in adult, has developed transgenic mice that express a dominant negative VEGF Receptor 2 that will be used to generate mice in which VEGF signaling can be inducably blocked. Each of these efforts addresses critical and previously under-investigated elements that directly impact the health and vision of our military personnel.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2002
- Accession Number
- ADA406994
Entities
People
- Patricia A. D'amore
Organizations
- Schepens Eye Research Institute