Pleiotrophin Signaling Through PTNR in Breast Cancer
Abstract
Angiogenesis, formation of new blood vessels, plays a key role in breast cancer growth by providing a method for hematogenous spread of the tumor, as well as providing nutrients for tumor metastasis. Rational treatment strategies for breast cancer must take into account the molecular mechanisms by which cancer develops, maintain its growth and finally spread to other parts of the body. The pleiotrophin (PTN) signaling pathway is known to be important in angiogenesis and breast cancer growth, but the exact mechanism by which PTN acts has not been elucidated. Recently, we identified a cell-surface receptor tyrosine kinase, anaplastic lymphoma kinase (ALK) receptor, as a receptor for PTN. In the previous report, we demonstrate the biological relevance of pleiotrophin signaling via ALK by targeting ALK with hammerhead ribozymes. In this report, we will demonstrate the role of the PTN/ALK interaction in tumor development and proliferation by overexpressing ALK dominant-negatives to disrupt PTN/ALK signaling.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2002
- Accession Number
- ADA407244
Entities
People
- Angera H Kuo
Organizations
- Georgetown University