Regulation and Role of Nuclear Receptor Coactivator AIB1 in Breast Cancer

Abstract

A1B1 (Amplified in Breast Cancer 1) is a nuclear receptor coactivator found amplified and overexpressed in a subset of breast cancers. A1B1 potentiates the transcriptional activity of the estrogen, progesterone, thyroid hormone, and retinoid receptors. It is necessary for normal female reproductive function and mammary gland development and is rate-limiting for tumor growth in nude mice.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2002
Accession Number
ADA407253

Entities

People

  • Kristina J. Lauritsen

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Culture Media
  • Enzyme Inhibitors
  • Gene Expression
  • Growth Factors
  • Hormones
  • Mammary Glands
  • Neoplasms
  • Proteins
  • Regulations
  • Retinoic Acids
  • Statistical Analysis
  • Tumor Cell Line

Fields of Study

  • Biology
  • Chemistry
  • Physics

Readers

  • Breast cancer cell signaling and growth regulation.