Interleukin-6 and Prostate Cancer Progression
Abstract
Prostate carcinoma (PCA) initially responds to androgen deprivation. However, it usually reoccurs in a form that is unresponsive to further hormonal manipulations. This latter form of PCA, termed androgen independent cancer, inexorably progresses resulting in the demise of the patient. Interleukin-6 (IL-6) and IL-6 receptor are expressed in PCA and activates the androgen receptor (AR) . In the current work we are exploring the hypothesis that IL-6 contributes to the progression of PCA that is observed post-androgen deprivation, through enhancing AR activity. In the current year's activity, we created cells that are stably transfected with an AR-green fluorescent protein (GFP) protein, we used these cells to determine that IL-6 activates the AR through several signal transduction pathways. We have also initiated several experiments to evaluate the ability of anti-IL-6 to prevent reestablishment of prostate cancer tumors in castrated mice. Finally, we have used an array technology to identify which transcription factors are activated by IL-6 in prostate cancer cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2002
- Accession Number
- ADA407280
Entities
People
- Evan T Keller
Organizations
- University of Michigan