Gene Controlling Susceptibility to Mammary Cancer

Abstract

This work examined the response of different mouse genotypes to the carcinogen 7,12-dimethylbenzAanthracene (DMBA). Genotype specificity for the particular tumors developed was observed; DMBA increased the incidence of and decreased the average age at which these tumors were observed. It does not appear that the genetic instability associated with the Werner Syndrome in humans enhances the predilection of mice to develop mammary cancer, even in animals dosed with the carcinogen DMBA. It was demonstrated that the dietary intervention of calorie restriction reduced the incidence of mammary tumors following carcinogen administration in genotypes predisposed to development of mammary cancers. An important finding is that in addition to genetic and environmental factors, there is a stochastic component involved in tumor development.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2002
Accession Number
ADA407281

Entities

People

  • Ruth D. Lipman

Organizations

  • Tufts University

Tags

DTIC Thesaurus Topics

  • Body Weight
  • Breast Cancer
  • Cells
  • Chemistry
  • Digestive System Processes
  • Diseases And Disorders
  • Drug Therapy
  • Gene Expression
  • Genetic Structures
  • Genetics
  • Health Services
  • Medical Personnel
  • Neoplasms

Fields of Study

  • Biology

Readers

  • Exercise and Sports Science.
  • Molecular and genetic basis of cancer.
  • Toxicology/Environmental Toxicology

Technology Areas

  • Biotechnology