Novel Approach for Evaluating and Treating Advanced Breast Cancer Patients Whose Tumors Overexpress HER-2/neu

Abstract

The goal of this research is to develop stable radioimmunoconjugates (RICs) of and-HER2/neu antibodies (MoAbs) for imaging and therapy in an animal model bearing human breast tumors. Pharmacy-grade Herceptin and an and-HER2/neu antibody were conjugated with a DTPA linker. (111)nCl3 and (90)YCI3 were labeled to MoAb-CHX-A"-DTPA according to the procedure of Clarke et al. (Cancer Res 60: 4804, 2000). Binding capacity of RICs was tested with human cancer cell lines MCF-7, HCC-1954, BT-474 and SKBR- 3.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2002
Accession Number
ADA407296

Entities

People

  • Jeffrey Medin
  • Micahel J. Blend
  • Steven M. Swanson

Organizations

  • University of Illinois at Chicago

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Breast Cancer
  • Cell Line
  • Cells
  • Diseases And Disorders
  • Epithelial Cells
  • Health Services
  • Infection
  • Medical Personnel
  • Neoplasms
  • Pharmacies
  • Proteins
  • Sodium Compounds
  • Tumor Cell Line

Fields of Study

  • Biology
  • Medicine

Readers

  • Oncology (Cancer Research).