Genetic Epidemiology of Prostate Cancer
Abstract
Prostate cancer results from complex interactions among genetic, endocrine, and environmental factors. The role of testosterone and other male hormones (androgens) in the development of prostate cancer is well documented. Understanding the genetic risk factors that contribute to the occurrence of prostate cancer is crucial to the design of both preventative and therapeutic strategies, and to identify at-risk individuals. This knowledge could reduce the incidence of and death from this disease. Important factors that may result in differences in individual risk for developing prostate cancer likely include genes involved in regulation of testosterone and cell growth in the prostate. The primary objective of this grant is to investigate changes in genes that directly and indirectly regulate levels of male hormones, which in turn, affect prostate cell growth, and may ultimately cause cancer. We have begun genotyping variants in DNA samples from the 199 prostate cancer cases and 254 unaffected age-matched male population controls currently available. Genotyping is almost complete for CYP11A1, CYP17, SRD5A2, IGF-1, IRS1, SHBG, and VDR. Statistical methods will be used to analyze the association of these genes with occurrence of prostate cancer, age at diagnosis and disease aggressiveness.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2002
- Accession Number
- ADA407311
Entities
People
- Susan L. Neuhausen
Organizations
- University of Utah