Molecular Determinants of Prostate Cancer Progression Across Race-Ethnicity. Project A - The Human 5RD5A2 Gene and Prostate Cancer Progression. Project B - Androgen Receptor (AR) Signaling in Prostate Cancer Progression. Project C - Cellular and Molecular Markers of Prostate Cancer Progression Core - Epidemiology Core
Abstract
This Prostate Cancer Center initiation grant has been designed to identify genetic and molecular markers of prostate cancer progression within and between racial ethnic groups (African-Americans, Latinos, Whites, Japanese) at substantially distinct underlying risk of prostate cancer. Our Epidemiology Core has obtained signed tissue releases from prostate cancer patients to date identified during follow-up of the Hawaii/Los Angeles Multiethnic Cohort study. Two hundred thirty-nine tissue samples have been received and processed histopathologically by Project C, which has begun immunohistochemical staining for COX-2, p27, p2l, p16 and Caveolin-l markers with additional markers to follow. Project B, studying the androgen receptor (AR) gene in detail, has identified 54 sequence variants in 90 samples analyzed to date. Two functional assays were developed this year to better assess these sequence variants. In Project A, studying the SRD5A2 gene in detail, in 87 tumors, the 13 mutations detected to date have been reconstructed by site-directed mutagenesis.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2002
- Accession Number
- ADA407343
Entities
People
- Brian E. Henderson
- Gerhard A. Coetzee
- Juergen Reichardt
- Richard Cote
- Ronald R. Ross
Organizations
- University of Southern California