Investigation of Alpha6 Integrins and Their Signaling Intermediate as Prognostic Markers for Breast Cancer

Abstract

We are investigating the role of alpah 6 beta 4 integrin expression in the progression of breast cancer. No amplification of the beta 4 gene was detected using probes derived from BAC clones. Cell lines MDA-MB-231 and BT474 (with high alpha 6 beta 4 expression) showed increased phosphorylation of PI3Kp110 but no change in the phosphorylation of P13Kp85 upon clustering surface beta 4. When surface alpha 6 was clustered, MDA-MB-23l and MDA-MB-l34 showed increased phosphorylation of FAK, and MCF-7 showed increased phosphorylation of Akt.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2002
Accession Number
ADA407363

Entities

People

  • Michael Z. Gilcrease

Organizations

  • The University of Texas MD Anderson Cancer Center

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Alkanes
  • Amplification
  • Antibodies
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Clustering
  • Hybridization
  • Integrins
  • Neoplasms
  • Phosphorylation
  • Proteins

Fields of Study

  • Biology
  • Chemistry

Readers

  • Analytical Mechanics
  • Breast cancer cell signaling and growth regulation.
  • Molecular Biology and Genetics