Targeting of Adenovirus Vectors to Breast Cancer Mediated by Soluble Receptor-Ligand Fusion Proteins

Abstract

The use of adenovirus (Ad) vectors for cancer gene therapy is currently limited by several factors, including broad Ad tropism associated with expression of coxsackie virus and adenovirus receptor (CAR) in normal human tissues, and limited CAR levels in tumor cells. To target breast cancer cell types, we proposed using soluble CAR (sCAR) ectodomain fused with a ligand to simultaneously achieve both blocking of CAR-dependent tropism and Ad infection through a novel receptor overexpressed in target cells.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2002
Accession Number
ADA407364

Entities

People

  • Elena A. Kashentseva
  • Igor P. Dmitriev

Organizations

  • University of Alabama

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Biomedical And Dental Materials
  • Blood
  • Breast Cancer
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Gene Delivery
  • Gene Expression
  • Gene Therapy
  • Growth Factors
  • Health Services
  • Neoplasms
  • Recombinant Proteins
  • Therapy
  • Tumor Cell Line
  • Viruses

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech