The Roles of Histone Deacetylase and DNA Methylation in Estrogen Receptor alpha Expression in Breast Cancer

Abstract

The proposal tests the hypothesis that hi stone deacetylase activity contributes to the transcriptional repression of the methylated estrogen receptor a (ER) gene. It further postulates that inhibition of histone deacetylase (HDAC) and DNA methylation may act together to reactivate the ER gene. Studies to date show that the HDAC inhibitor trichostatin A, can reactivate ER expression in ER- negative breast cancer cell lines. Combined treatment with HDAC inhibitors and demethylating agents can synergistically reactivate expressions of ER in ER-negative breast cancer cell lines.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2002
Accession Number
ADA407368

Entities

People

  • Yi Huang

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Breast Cancer
  • Carrier Proteins
  • Cell Line
  • Cells
  • Chemical Reactions
  • Chromosome Structures
  • Drug Abuse
  • Enzyme Inhibitors
  • Gene Expression
  • Maryland
  • Materials
  • Neoplasms
  • Polymerase Chain Reaction
  • Regulations
  • Tumor Cell Line

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular and genetic basis of cancer.