Genetic Determinants of Aromatase Expression and Susceptibility to Postmenopausal Breast Cancer

Abstract

The major source of estrogen in postmenopausal women is conversion of androstenedione in adipose tissue to estrone by the enzyme aromatase. In adipose tissue, the aromatase gene, CYP19, is regulated by the cytokines TNF-alpha and IL-6, which act on a regulatory region of the CYP19 gene called the 1.4 promoter. The objective of this study is to determine whether polymorphism in the TNF-alpha gene, in the IL-6 gene, or in the CYP19 gene 1.4 promoter is associated with (1) the plasma estrone (El) to androstenedione (A) ratio, a phenotypic measure of aromatase expression, or with (2) risk of post- menopausal breast cancer. This investigation is being carried out using DNA and serum samples from 1360 women enrolled in the Hawaii-Los Angeles Multiethnic cohort study.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2002
Accession Number
ADA407426

Entities

People

  • Sue A. Ingles

Organizations

  • University of Southern California

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Adipose Tissue
  • African Americans
  • Biomedical Research
  • Breast Cancer
  • California
  • Classification
  • Detectors
  • Ethnic Groups
  • Frequency
  • Genes
  • Information Operations
  • Neoplasms
  • Security
  • Sequences
  • Tissues

Readers

  • Immunology and Pathology
  • Molecular Genetics
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech