Early Detection Based on Angiogenic Growth Factors in Nipple Aspirate Fluid
Abstract
The objective of this proposal is to develop new methods of early breast cancer detection by identifying increases in angiogenic growth factor secretion in nipple aspirate fluid (NAF) . Specifically, the study is examining basic fibroblast growth factor (FGF-2) and vascular endothelial growth factor (VEGF), two of the most potent angiogenic molecules whose expression is thought to increase as an early event in breast carcinogenesis. This project has been delayed repeatedly by unavoidable problems in staffing, collaborators leaving the institution, the Pi's own move to a different institution, institutional IRE problems, and competition for patients. The net result is that, at the conclusion of the funding period, sufficient patient samples have not been accrued to complete the study goals. However, the PI has funding from the National Cancer Institute to study other potential biomarkers of early detection in NAF, specifically protein expression patterns. Samples from this study will he used to supplement those already obtained with DOD funding, and analyses for FGF-2 and VEGF will be performed using institutional funds available to the PI.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2002
- Accession Number
- ADA407437
Entities
People
- Bruce J Trock
Organizations
- Georgetown University