Functional Characterization of the Murine Homologue of PLAB, a Novel TGF-B Member, in Placental and Mammary Tissues
Abstract
The relationship of extraembryonic membrane function to the progression of cancers, specifically cancers of the breast, is an understudied area of research. By understanding the factors, which control the molecular architecture of the placenta and other fetal membranes, we hope to shed light on mechanisms by which placental function is established. The initial goal of this research had been to characterize the role of the gene mPlab in mice conditionally null for the gene. mPlab is a member of the TGF-BETA superfamily of transforming growth factors, and had been previously demonstrated to be expressed at highest levels in the developing placenta. Midway through our research, we discovered that another laboratory had published the phenotype of the mPlab deficient mice (1). In light of this, we were forced to abandon our research on mPlab and find other areas of fetal membrane research to explore. In this report, we detail the completed work on our revised proposal. Additionally, the DOD had indicated that it would not be willing to fund research requiring work with non-human primate materials as described in the annual report dated June 2001. In order to alleviate these concerns, we submit a modification of the new research proposal to the reviewing boards.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2002
- Accession Number
- ADA407448
Entities
People
- Guy S. Eakin
Organizations
- The University of Texas MD Anderson Cancer Center