Maturation Phenomenon in Cerebral Ischemia IV

Abstract

Young animals were previously shown to be more resistant to ischemia than were adult animals. This difference was attributed to maturation/function of gonads and/or neurons. This study evaluated the existence of age-related changes in transcriptional expression of HSC70, HSP72, and c-fos mRNA intransient global ischemia, and their possible relationship to neuronal cell survival in CA1 hippocampus. The results indicated that ischemic response in young animals compared with that in adult animals showed: (1) more rapid and /or prolonged expression of HSC70, HSP72, and c-fos mRNAs; (2) a marked induction of HSP72 protein; and (3) enhanced pyramidal cell survival. The observed endogenous 'tolerance' of CA1 neurons in young gerbils to ischemia/reperfusion injury may be related to the expression of HSC70, HSP72 and c-fos.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2001
Accession Number
ADA407512

Entities

People

  • I. Klatzo
  • N. G. Bazan
  • T. Kuroiwa
  • U. Ito
  • V. L. Marcheselli

Organizations

  • Naval Medical Research Center

Tags

DTIC Thesaurus Topics

  • Arteries
  • Blood
  • Blood Flow
  • Brain
  • Cell Physiological Processes
  • Cerebrovascular Disorders
  • Congress
  • Growth Factors
  • Health Services
  • Ischemia
  • Law
  • Materials
  • Necrosis
  • Proteins
  • Surgery
  • Vascular Diseases

Fields of Study

  • Biology

Readers

  • Immunology
  • Neuroscience
  • Trauma Surgery or Emergency Medicine.