The p202 Gene as a Tumor Suppressor in Prostate Cancer Cells
Abstract
This current proposal is based on our previous observations that: (1) Interferons (IFNs) are capable of exerting growth inhibition and anti-tumor effects on human cancer cells; and (2) p202 expression alone is sufficient to suppress both cell growth and tumor development of human prostate and breast cancer cells. To further investigate the anti- tumor activity of p2O2 on prostate cancer and to develop a p202 gene therapy for prostate cancer, we have proposed three specific aims to accomplish our objectives. Aim 1: To determine the anti-tumor and the pro-apoptotic activities of p202 in prostate cancer cells; Aim 2: To understand the molecular mechanisms underlying the p202-mediated anti-growth, anti-tumor, and potential pro-apoptosis activities in prostate cancer; Aim 3: To test the anti-tumor activity of p202 in prostate cancer cells using preclinical gene therapy strategies and to determine the efficacy of a combined treatment with TNF-alpha in an orthotopic prostate cancer animal model. Success of those aims will constitute a scientific basis for p202-associated anti-tumor effect on prostate cells and will enable us to develop a novel p202 gene therapy strategy against prostate cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2002
- Accession Number
- ADA407537
Entities
People
- Mien-Chie Hung
Organizations
- The University of Texas MD Anderson Cancer Center