The Role of the Integrin-Linked Kinase (ILK) in Mammary Gland Tumorigenesis and Metastasis

Abstract

The major objective of our DOD sponsored research program is to assess the role od the integrin linked kinase in mammary tumorigenesis and metastasis. Based on previous observation that ILK is overexpressed in human breast cancers, we have derived several independent transgenic strains that express ILK in the mammary epithelium. Genetic and biochemical analysis of these strains revealed that female transgenic strains developed focal mammary tumors after a long latency period. Interestingly mammary tumors derived from these strains have undergone epithelial-mesemcyhmal transition (EMT) . The results of these studies provide direct evidence that overexpression of ILK may be an important step in mammary tumor progression.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2002
Accession Number
ADA407546

Entities

People

  • William Muller

Organizations

  • McMaster University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Breast Cancer
  • British Columbia
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemistry
  • Cytoskeleton
  • Epithelial Cells
  • Epithelium
  • Health Services
  • Mammary Glands
  • Metastasis
  • Neoplasms
  • Tumor Cell Line

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics

Technology Areas

  • Biotechnology