The Role of Fps in Tumor-Associated Angiogenesis
Abstract
Angiogenesis plays a critical role in the development of many types of tumors, including mammary tumorigenesis REVIEWED IN (6, 7). Transgenic expression of an activated form of the cytoplamic tyrosine kinase Fps gave rise to mice with pronounced hyperplasia implicating this kinase in angiogenic mechanisms (3). Our work to date has focused on numerous aspects of the angiogenic mechanism that may potentially involve Fps which has led to several developments along this line of investigation. Many of these developments specifically address Objectives in the Statement of Work which were designed to investigate the nature of the role of Fps in angiogenesis. However, other developments have also arisen that were not originally anticipated. These developments have further illuminated how Fps may regulate angiogenic mechanisms. In addition to angiogenesis, Fps has also been implicated in coagulation, immunity, and inflammation REVIEWED IN (5), all of which are highly inter-related and are very relevant to the process of tumorigenesis. Thus, Fps may play an important role in modulating tumorigenesis not only through angiogenesis, but through these other processes as well. Understanding how Fps may fulfill this role will be crucial for developing specific therapeutics designed to combat breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2002
- Accession Number
- ADA407620
Entities
People
- Peter A. Greer
- Waheed Sangrar
Organizations
- Queen's University