Protein Kinase Pathways that Regulate Neuronal Survival and Death
Abstract
Loss of post-mitotic neurons from the adult brain underlies the pathology of neurodegenerative diseases and neurotoxin expostire Neuronal cell death occurs by two mechanisms: necrosis and apoptosis. Apoptosis is a process whereby developmental cues and environmental stimuli activate a genetic program to implement a series of steps that culminate in cell death. An important aspect of apoptosis is that it can be halted and such interventions may rescue dying neurons. The overall goal of this project is to identity key protein kinases involved in regulating neuronal survival and apoptosis. The aims for the this year of funding as described in the Statement of Work were to: 1) Continue studies on protein kinase cascades that regulate neuronal survival, 2) Modulate the protein kinase cascades regulated by neurotrophic factors and determine the consequence on neuronal survival and death, and 3) Begin studies examining the cross-talk in pro-apoptotic and anti-apoptotic protein kinase signaling cascades. The progress made in these areas has resulted in 4 published manuscripts (plus 2 submitted articles) and 9 abstracts presented at national and international scientific meetings in 2002.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2002
- Accession Number
- ADA407641
Entities
People
- Kim A. Heidenreich
Organizations
- University of Colorado Health