Environmental Exposures at Birth and at Menarche and Risk of Breast Cancer
Abstract
This is a population-based study that examines location of residence at birth and menarche in relation to proximity to industrial sites, gasoline stations, toxic waste sites and heavily trafficked roadways as risk factors for subsequent breast cancer. It also examines estimated exposure to benzene and to PAHs as risk factors and evaluates genetic susceptibility in relation to these exposures and breast cancer. There are 15,969 individual addresses, representing 3,091 participants in Erie and Niagara counties, in the study. A validation study was conducted to assess the positional accuracy of addresses geocoded in the GDT enhance TIGER file using a Global Positioning System (GPS). Blood samples from all participants with samples have been sent for DNA extraction and genotyping. Standard Industrial Classification (SIC) directories are being used to categorize exposure groups and to geocode point sources of pollution. To date, 13 uranium processing sites and 8 steel mill sites have been geocoded and proximity to birth residence established. Clustering analysis was conducted to identify geographic patterns of residence for breast cancer cases and controls at critical time periods.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2002
- Accession Number
- ADA407767
Entities
People
- Jo L Freudenheim
Organizations
- University at Buffalo