Structure and Function of AIB1 (Amplified in Breast Cancer-1) Protein
Abstract
The overexpression or amplification of the AIB1 gene is observed in the majority of primary breast tumors, and is also correlated with a large percentage of hereditary and sporadic ovarian carcinomas. The AIB1 protein is a member of the steroid receptor coactivator family of transcriptional regulatory proteins that contain a conserved C-terminal histone acetyltransferase domain, and an N-terminal bHLH-PAS domain. We hypothesize that the HAT and bHLH-PAS domains of AIB1 play critical roles in mediating elevated transcriptional activation levels in AIB1-mediated cancers. The goal of this proposal is to determine the three dimensional structure of the HAT and bHLH-PAS domains of AIB1 to facilitate the structure-based design of small molecule inhibitors to specifically target AIB1 1 for therapeutic application.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2002
- Accession Number
- ADA408058
Entities
People
- Ronen Marmorstein
Organizations
- University of Pennsylvania