Neural Protein Synuclein Gamma (SNCG) in Breast Cancer Progression
Abstract
Synucleins are emerging as a central player in the fundamental neural processes and in the formation of pathologically insoluble deposits characteristic of Alzheimer's (AD) and Parkinson's (PD) diseases. Most studies of this group of proteins have been directed to the elucidation of their role in the formation of depositions in brain tissue. However, the normal cellular function of this highly conserved synuclein family remains largely unknown. In addition, synucleins have also been implicated in non-neural diseases particularly in the hormone-responsive cancers of breast and ovary. Using differential cDNA sequencing approach, we first identified a breast cancer specific gene, BCSG1, which was expressed abundantly in metastatic breast cancer cDNA library but scarcely in normal breast cDNA library. Interestingly, BCSG1 revealed no homology to any other known growth factors or oncogenes; rather, BCSG1 revealed extensive sequence homology to neurotic proteins of alpha synuclein and beta synuclein, and thus was also named as gamma Synuclein (SNCG). SNCG expression is highly associated with breast cancer and ovarian cancer progression.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2002
- Accession Number
- ADA408074
Entities
People
- Yangfu Jiang
Organizations
- Long Island Jewish Medical Center