A Molecular Model for Repression of BRCA-1 Transcription by the Aryl Hydrocarbon Receptor

Abstract

The purpose of this project is to investigate whether or not regulation of expression of the BRCA-1 gene in breast epithelial cells exposed to polycyclic aromatic hydrocarbons (PAHs) is mediated by the aryl hydrocarbon receptor (AhR). The scope of the project is to examine whether or not the AhR complexed with the AhR-nuclear transporter (ARNT) protein, binds to several xenobiotic responsive elements (XRE) strategically located at -539 bp (CCGTGGAA=Cyp1A1-like) and +20base pairs (bp) (GCGTG=XRE-1) from the transcription start site on exon-1A.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2002
Accession Number
ADA408088

Entities

People

  • Donato F. Romagnolo

Organizations

  • University of Arizona

Tags

DTIC Thesaurus Topics

  • Aromatic Hydrocarbons
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Physiological Processes
  • Chemistry
  • Cyclic Hydrocarbons
  • Environmental Health
  • Gene Expression
  • Hydrocarbons
  • Indicator Dyes
  • Mammary Glands
  • Neoplasms
  • Polymerase Chain Reaction
  • Proteins
  • Tissue Extracts
  • Transcription Factors

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular Genetics
  • Organic Chemistry