Role of PTPase LAR in EGF Receptor Signaling in Mammary Gland
Abstract
The epidermal growth factor receptor (EGFR) is an important mediator of breast cancer tumorigenesis and metastasis. While much is known about EGFR signal transduction related to its tyrosine kinase activity, less is known about the protein tyrosine phosphatases (PTPs) which must be present to modulate the cellular effects of the EGFR by dephosphorylating the receptor and its substrates. Evidence derived from several approaches suggests that the transmembrane PTP LAR may be involved in EGFR signaling in mammary gland development and tumorigenesis. The hypothesis to he tested in this proposal is that LAR plays an important role in EGFR-dependent mammary gland development and tumorigenesis through negative modulation of EGFR signal transduction. Work in the second year has supported this hypothesis. LAR expression is also shown to be regulated by cell density, with concentrations increasing markedly as cell density increases. Functional E-cadherin complexes are necessary for this effect.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2002
- Accession Number
- ADA408090
Entities
People
- Robert A. Mooney
Organizations
- University of Rochester