Novel Histone Deacetylase Inhibitors

Abstract

The goal of this project is to develop new drugs for cell differentiation therapy of breast cancer. Our central hypothesis is antimalarials and structurally related quinoline compounds are histone deacetylase inhibitors and cause breast tumor cell differentiation and apoptosis. We have screened 21 compounds: 9 antimalarials and 12 additional quinoline ring bearing NSC compounds. Five novel breast tumor cell differentiation agents were identified, none of which was a direct inhibitor of histone deacetylase, and therefore promote breast tumor cell differentiation by novel mechanism(s). Two new histone deacetylase inhibitors were identified. Four (NSC 10010, NSC 305819, chloroquine and quinidine) of the 7 compounds also promoted apoptosis in cultured breast cancer cells. We conclude that these 4 quinoline ring compounds warrant further investigation as potential breast cancer therapeutic agents.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2002
Accession Number
ADA408095

Entities

People

  • Anna R. Martirosyan
  • Jeannine S. Strobl

Organizations

  • West Virginia University

Tags

DTIC Thesaurus Topics

  • Biomedical And Dental Materials
  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Enzyme Inhibitors
  • Genetics
  • Health Services
  • Neoplasms
  • Organic Chemistry
  • Polymer Chemistry
  • Polymeric Films
  • Proteins
  • Tumor Cell Line

Fields of Study

  • Biology
  • Chemistry
  • Medicine

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