Novel Histone Deacetylase Inhibitors
Abstract
The goal of this project is to develop new drugs for cell differentiation therapy of breast cancer. Our central hypothesis is antimalarials and structurally related quinoline compounds are histone deacetylase inhibitors and cause breast tumor cell differentiation and apoptosis. We have screened 21 compounds: 9 antimalarials and 12 additional quinoline ring bearing NSC compounds. Five novel breast tumor cell differentiation agents were identified, none of which was a direct inhibitor of histone deacetylase, and therefore promote breast tumor cell differentiation by novel mechanism(s). Two new histone deacetylase inhibitors were identified. Four (NSC 10010, NSC 305819, chloroquine and quinidine) of the 7 compounds also promoted apoptosis in cultured breast cancer cells. We conclude that these 4 quinoline ring compounds warrant further investigation as potential breast cancer therapeutic agents.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2002
- Accession Number
- ADA408095
Entities
People
- Anna R. Martirosyan
- Jeannine S. Strobl
Organizations
- West Virginia University