The Role of PRIP in Breast Cancer
Abstract
Estrogen plays an important role in the normal breast and breast cancer development. Estrogens exert their cellular effects through ER that is a member of nuclear receptor superfamily. PRIP (Peroxisome proliferator receptor interacting protein) is a nuclear receptor coactivator that is amplified and overexpressed in breast cancer. The proposal was to investigate how the PRIP dysregulation contributes to abnormal growth and neoplastic development of breast. During the first year of the award, we have generated transgenic mice with integrated MMTV-PRIP lineages and heterozygous mice with conditional inactivated PRIP gene. About fifty estrogen- inducible genes have been identified by microarray hybridization. PRIP overexpression and amplification were found in about 60% and 10% of the breast cancers, respectively. PIMT (PRIP interacting protein with a methyltransferase domain) which interacts with and enhances nuclear receptor coactivator PRIP function was identified. PRMT2(protein arginine methyltransferase 2) was found to act as a coactivator for estrogen receptor alpha. These findings not only advanced our understanding of estrogen signaling pathway but also suggested that nuclear receptor coactivator PRIP plays an important role in the breast cancer development.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2002
- Accession Number
- ADA408106
Entities
People
- Janardan K. Reddy
- Sunil S. Badve
- Yijun Zhu
Organizations
- Northwestern University