Recycling of HER-ErbB Receptors: Rescue From Apoptosis and Targets for Immunotherapy
Abstract
Signals to multiply, migrate and outgrow blood vessels are mediated by growth factors of the EGF/neuregulin family. Concentrating on the membrane receptors for EGF and neuregulins, namely tyrosine kinases of the ErbB/HER family, our first task is to resolve mechanisms that normally restrain ErbB receptors. These efforts have led to the identification of a regulatory loop that allows collaboration between ErbB receptors and c-Src, a major oncoprotein of breast cancers. According to our findings, c-Src phopshorylates c-Cb1, a major restrainer of ErbB signaling, and leads to its proteasomal destruction. Consequently, tumor cells overexpressing c-Src or active Src mutants are unable to down-regulate ErbB proteins. Our Task 2 relates to a putative particle that modulates recycling of ErbBs. We report on the function of two components, Hgs and STAM, and their regulation by an ubiquitin ligase called Need4.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2002
- Accession Number
- ADA408134
Entities
People
- Yosef Yarden
Organizations
- Weizmann Institute of Science