Kinase Independent Functions of Cyclin D1 Which Contribute to its Oncogenic Potential In Vivo
Abstract
Cyclin D1, an important cell cycle regulator, is a potent oncogene in several tumor types, including breast cancer. The most well understood function of cyclin D1 is to bind and activate cdks 4 and 6. One target of these kinases is pRb. Upon phosphorylation, pRb is inactivated, and cells pass from G1 into S phase. We and others have demonstrated that cyclin D1 has other functions, many of which are independent of kinase activity in vino. In vivo demonstration of kinase independent functions of cyclin D1 may help elucidate the underlying mechanisms of cyclin D1 oncogenicity. To determine whether cyclin D1 has important kinase-independent functions in vivo, we are generating a cyclin D1 K112E knock-in mouse.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2002
- Accession Number
- ADA408164
Entities
People
- Mark W. Landis
- Philip W. Hinds
Organizations
- Harvard Medical School