Mouse Mammary Cancer Models - Mechanisms and Markers
Abstract
We have generated and characterized several mouse models to better understand the role of breast cancer associated genes in an experimentally manipulable context. We have focused on the role of p53 and p53 target genes and their role in promoting mammary cancer. Recent emphasis has been placed on the Wild type p53-Induced Phosphatase (Wip1), also known as Ppm1D. This gene has recently been demonstrated to be an oncogene in vitro and to be specifically amplified in more than 15% of human breast cancers. To study the role of Wip1 in mammalian development, physiology, and cell cycle control, we generated knockout mice that are deficient in Wip1. Wip1-deficient mice exhibit multiple developmental defects and their cells show defects in cell cycle progression. We have confirmed that Wip1 is radiation-induced p53 target gene and we have identified three novel potential Wip1 interacting proteins.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2002
- Accession Number
- ADA408687
Entities
People
- Lawrence A. Donehower
Organizations
- Baylor College of Medicine