Molecular Epidemiology of Breast Cancer in Korean Women
Abstract
This project is testing the hypothesis that breast cancer in elderly women represents a disease different than breast cancer in young women The hypothesis is being tested using gene expression profiles as objective measures of breast cancer phenotypes. The study is being conducted using samples from Korean women because this likely represents a relatively homogeneous population from genetic and cultural perspectives. The proposed first phase of the project is to identify genes that are differentially expressed in a small set of breast cancers from young and elderly women. While we have been technically successful in conducting these studies as proposed, we have not found consistent differences in gene expression patterns between cancers from young and elderly patients. The second phase of this project is to construct a custom array that represents candidate genes far differentiating the cancers from young and elderly women. We will begin constructing this array soon, using genes that are differentially expressed among different breast cancers Subsequent experiments will measure gene expression profiles in additional samples of breast cancers from Korean women and ultimately North American women.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2002
- Accession Number
- ADA408692
Entities
People
- Edward W. Gabrielson
Organizations
- Johns Hopkins University