Magnetic Resonance Studies of Photosensitizers and Their Effect in Tumors
Abstract
The main goal of this project is to study the fluorine labeled photosensitizers in the treatment of tumor models of relevance to breast cancer by photodynamic therapy. This study will use 19F MR spectroscopy to determine the accumulation of photosensitizers in the tumor mass and the time at which maximum accumulation occurs in the tumor. Tumor destruction is achieved via appropriate laser irradiation when there is maximum amount of photosensitizer in the tumor volume. The rate of absorption and the peak times will be obtained to perform photodynamic therapy(PDT) studies involving the labeled photosensitizers. In vivo Phosphorous-31 NMR will be utilized before and after initiation of PDT to determine the effectiveness of this spectroscopic technique in predicting PDT outcome. Finally the 1H MR diffusion imaging will be performed at several time points post PDT treatment to obtain a complete picture of tumor necrosis and tissue viability. The combined use of the multinuclear techniques on tumor model can provide significant information towards breast cancer treatment by PDT.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2002
- Accession Number
- ADA408716
Entities
People
- Subbaraya Ramaprasad
Organizations
- University of Nebraska Medical Center