Molecular Mechanisms of Soft Tissue Regeneration and Bone Formation in Mice: Implications in Fracture Repair and Wound Healing in Humans
Abstract
The primary goal of the proposed work is to identify genes which play an anabolic role in bone and soft tissue function and to clarify the function of these genes. Three hypotheses have been proposed:1) the high bone density gene in chromosome 1 in our CAST/B6 congenic mice can be clones; 2) Genes that regulate soft-and hard-tissue regeneration can be identified by using appropriate mouse strains that exhibit differences in regeneration; and 3) ENU mutagenesis, applied to our mouse model, will lead to the identity of genes that regulate soft and hard tissue function. During the last funding period, we have proposed several specific objectives for each of the above mentioned hypothesis. As disclosed in the progress report, we have successfully accomplished all of the specific objectives. Our work during this reporting period has resulted in three published manuscripts, one manuscript in press, one submitted manuscript, one manuscript under revision for publication, and two abstracts. We believe that successful accomplishment of the proposed studies will provide a better understanding of the molecular mechanisms involved in hard- and soft-tissue regeneration and will provide a framework for future development of therapies for hard and soft tissue injuries.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2002
- Accession Number
- ADA408806
Entities
People
- David J. Baylink