National Department of Defense Surveillance for Invasive Streptococcus Pneumoniae: Antibiotic Resistance, Serotype Distribution, and Arbitrarily Primed Polymerase Chain Reaction Analyses
Abstract
To provide surveillance among United States military personnel and their beneficiaries, we systematically collected invasive S. pneumoniae clinical isolates from seven health care sites between July 1997 and August 1999. Antibiotic testing was performed on 157 isolates, and 120 of these isolates were serotyped and subjected to DNA fingerprinting. Fifty (31.9%) of the 157 isolates had partial or full resistance to penicillin and 17.5% had multidrug resistance. The most common serotypes were 4, 6B, 9V, 14, 1 9F, and 23F. The serotypes associated with penicillin resistance were 6B, 9V, 14,1 9A and 23F. Eighty-eight percent of the cases seen were potentially preventable through the use of currently available pneumococcal vaccines. Using arbitrarily primed PCR, we found four DNA fingerprint groups which had a high correlation with health care site (p value </-0.0001). These results are valuable in assessing appropriate use of antibiotics and vaccines against S. pneumoniae in military beneficiaries.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2001
- Accession Number
- ADA408907
Entities
People
- Anthony W. Hawksworth
- Christopher P. Barrozo
- Margaret A.K. Ryan
- Marie K. Hudspeth
- Tyler Clain Smith
Organizations
- Naval Health Research Center