Evaluation of Response to Induction Therapy in Breast Cancer with Phosphorus-31 Magnetic Resonance
Abstract
The objective of the proposed research is to develop IR-decoupled 31P magnetic resonance spectroscopy (MRS) techniques for measuring non-invasively the response of breast cancer to induction or preoperative chemotherapy. We hypothesize that the quantitative assessment of the effectiveness of a treatment using 31P MRS will be clinically feasible at 3.OT. During this reporting period, a double tuned breast RF coil was built and tested. The coil was based on a commercial coil body, and tuning elements appropriate for the 3.0 T field strength were installed. The clinical scanner, nominally designed as a proton-only instrument, was converted to operate on the phosphorus frequency by suitable modification of the transmitter and receiver electronics. The coil may therefore be used to obtain proton scout images, and then switched to phosphorus for reception of spectra.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2002
- Accession Number
- ADA408994
Entities
People
- Jerome L. Ackerman
Organizations
- Massachusetts General Hospital