Cell-Specific Ionic Models of Cardiac Pacemaker Activity

Abstract

We have developed a generic ionic model of single-cell rabbit sinoatrial node (SAN) electrical activity, employing Markov-state kinetics for membrane ionic currents. By suitable choice of parameters, the model is able to accurately reproduce a wide range of action potential waveforms recorded from individual SAN cells in the laboratory. Advantages of this approach include the ability to quantitatively investigate the contribution of ion currents underlying pacemaker and action potential activity from any given SAN myocyte recording.

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Document Details

Document Type
Technical Report
Publication Date
Oct 25, 2001
Accession Number
ADA409210

Entities

People

  • A. Zaza
  • N. H. Lovell
  • S. Dokos
  • S. L. Cloherty

Organizations

  • University of New South Wales

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Biology
  • Biomedical Engineering
  • Biotechnology
  • Cell Membrane
  • Cells
  • Classification
  • Engineering
  • Heart Conduction System
  • Linear Programming
  • Mathematical Models
  • Membrane Potentials
  • Membranes
  • Military Research
  • Models
  • Pacemakers
  • Waveforms

Fields of Study

  • Biology

Readers

  • Cardiovascular Physiology
  • Neuroscience
  • Plasma Physics.