Oxidative Damage, CYP1B1 and Breast Cancer

Abstract

Oxidative damage to DNA has been shown to occur in vivo indicating that DNA can be damaged as a consequence of normal metabolism. Because a large number of DNA base modifications are caused by oxidative stress, it is difficult to measure the whole spectrum of modified lesions. One of the more abundant lesions, 8-hydroxy- 2'deoxyguanosine (8-oxoG), which is known to cause a 0 to T transversion, is used as a reliable index of overall oxidative DNA damage. DNA bases modified by oxidative stress can lead to mutations, chromosomal abnormalities and altered gene expression.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2002
Accession Number
ADA409396

Entities

People

  • Regine Goth-goldstein

Organizations

  • University of California, Berkeley

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cancer
  • Cells
  • Chemistry
  • Epithelial Cells
  • Estrogens
  • Free Radicals
  • Gene Expression
  • Genetic Variation
  • Hydrocarbons
  • Materials
  • Medical Personnel
  • Metabolism
  • Neoplasms
  • Oxidative Stress
  • Statistical Analysis
  • Test Methods

Readers

  • Immunology and Pathology
  • Molecular Genetics
  • Oncology and Biomarker-Based Cancer Detection.