Identification and Characterization of Novel Antimitotic Compounds for the Treatment of Breast Cancer

Abstract

Antimitotics are drugs that kill cancer cells by causing them to arrest in mitosis. Antimitotics currently used in breast cancer therapy include paclitaxel, vincristine and vinbiastine. Although these drugs are extremely valuable, they are not ideal because they have serious side effects, and, most importantly, many breast cancers are resistant to them. Our goal was to find new antimitotic drugs for the treatment of breast cancer using a novel cell-based assay to screen natural product libraries and guide the purification of their active components.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2002
Accession Number
ADA409399

Entities

People

  • Michel Roberge

Organizations

  • University of British Columbia

Tags

DTIC Thesaurus Topics

  • Alkenes
  • Aquatic Organisms
  • Biological Products
  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Cyclic Hydrocarbons
  • Fungi
  • Liquid Chromatography
  • Molecular Biology
  • Neoplasms
  • Organic Chemistry

Readers

  • Molecular and Cellular Biochemistry
  • Oncology (Cancer Research).