Spectral Changes of Lung Cancer Serum in the Process of Tumor Evolution
Abstract
The discrimination and changes of serum fluorescence and Raman spectrum for normal human, lung cancer patient and one after operation in different period and extent were studied. We kept close watch on the tumor progression of a group of patients, and measured their serum spectra using 488.0nm and 514.5nm excitation of an Ar-ion laser once a week. There was no apparent change observed in fluorescence spectrum in different period. However, the relative intensity of three Raman peaks (mode A, B, and C) decreased every week later. For quantitative analysis of such changes, a parameter I(sub r) (relative intensity of C Raman peak) was introduced and I(sub r-)value was calculated. Calculation showed that I(sub r-)value was digressive with tumor evolution, but caret-a (I sub r5145/I sub 4880) varied irregularly. To the end, no Raman peak was observed. We assumed that three Raman peaks were derived from beta carotene. It indicated that the content of beta carotene decreased with the aggravation of lung cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 25, 2001
- Accession Number
- ADA409676
Entities
People
- Huiqiang Jin
- Xiaozhou Li
- Zhongqiu He
Organizations
- Liaoning University