Organosulfur Compounds as ChemDefense Agents - Mustard

Abstract

Organosulfur compounds have demonstrated protective activity against sulfur mustard (HD), bis(2-chloroethyl) sulfide. Twenty three compounds, many representing new compositions of matter, have been prepared in the first half of this program. These include derivatives of thiavitamin E, glutathione, thiacholesterol, pyridine and benzothiazole. The program has expanded the ability to prepare unsymmetric disulfides of interest and the utility of 2- mercaptobenzothiazole and alkoxycarbonylsulfenyl chlorides in this program. These compounds, largely based upon monothiols, form the platform upon which to develop targets related to BAL and related systems. We currently are awaiting details of bioassay studies.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2001
Accession Number
ADA409740

Entities

People

  • Andrew L. Ternay Jr

Organizations

  • University of Denver

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Acetic Acid
  • Alcohols
  • Aluminum Oxides
  • Bioassay
  • Chemistry
  • Chlorides
  • Column Chromatography
  • Desiccants
  • Equations
  • Ethers
  • Hydroxides
  • Materials
  • Oxides
  • Pyridines
  • Silica Gels
  • Sodium Hydroxide

Fields of Study

  • Chemistry

Readers

  • Aerospace Research.
  • Analytical Chemistry
  • Organic Chemistry