The Role of the Insulin-Like Growth Factor (IGF) Binding Proteins (IGFBPs) in IGF-Mediated Tumorigenicity

Abstract

The insulin-like growth factor (IGF) system has been shown to play an important role in the progression of a number of cancers, including breast cancer. IGF-1 binds with high affinity to a family of proteins known as the IGF binding proteins (IGFBPs), which act as natural inhibitors of IGF-1 through sequestration from the IGF-1 receptor. The purpose of this proposal is the development of IGF antagonists based on the structure of the IGFBPs. Knowledge of the mechanism of IGFBP action is currently unclear, therefore we have taken a photoaffinity labeling approach to identify the IGF binding domains on the IGFBPs.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2002
Accession Number
ADA409808

Entities

People

  • Caroline E. Harbeson
  • Steven A Rosenzweig

Organizations

  • Medical University of South Carolina

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Biochemistry
  • Breast Cancer
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Gel Electrophoresis
  • Growth Factors
  • Liquid Chromatography
  • Mass Spectra
  • Mass Spectrometry
  • Neoplasms
  • Organic Chemistry
  • Polymer Chemistry
  • Protein Sequence Analysis
  • Proteins
  • Spectrometry

Readers

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