Alpha Synuclein in a Model of Multiple System Atrophy

Abstract

Multiple system atrophy (MSA) is a progressive neurological disorder characterized by parkinsonism, cerebellar dysfiinction and autonomic impairment. The cardinal pathological feature of MSA is the glial cytoplasmic inclusion (GCI) in oligodendrocytes, and a major component of GCIs is oc-synuclein. We identified a rat oligodendrocytic precursor cell line (CG-4) that produces a-synuclein and characterized oc-synuclein in the cells and production of a-synuclein after differentiation to mature oligodendrocytes and astrocytes. Studies to date suggest that oxidative stress can cause aggregation of a-synuclein. We have further developed CG-4 cells that can overexpress human a-synuclein constitutively or under the control of a tetracycline inducible promoter.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2002
Accession Number
ADA409812

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Antibodies
  • Astrocytes
  • Biomedical Research
  • Cell Line
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Gel Electrophoresis
  • Infection
  • Mass Spectrometry
  • Materials
  • Organic Chemistry
  • Oxidative Stress
  • Proteins
  • Two Dimensional
  • Wound Infections

Fields of Study

  • Biology
  • Medicine

Readers

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