Effect of Calcium-Activated Chloride Current Blockade on the Delayed Afterdepolarizations. Simulation Study

Abstract

High intracellular calcium conditions cause a calcium-activated transient inward current (I to the ti) that can provoke oscillations in membrane potential called delayed afterdepolarizations (DAD)). The current I to the ti comprises of the sodium-calcium exchange current (I to the CI-Ca) and the calcium activated chloride current (1ci-ca) Lindblad, Murphey, Clark and Ciles developed a mathematical model (LMCC model) of the rabbit atrial AP, In this study, a modified AP LMCC model that includes I to the ci-ca is used to evaluate the contribution of I to the ci-ca to develope DADs, Our results suggest that although I to the NaCa is the main component of I to the ti ( 65% ), I to the ci-ca may play a significant role in DAD generation, Even more, the I to the ci-ca blockade could inhibit the DAD propagation and trigger activity associated to high Ca2+ condition, in atrial tissue,

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Document Details

Document Type
Technical Report
Publication Date
Oct 25, 2001
Accession Number
ADA409881

Entities

People

  • J. Gomis-tena
  • J. Saiz

Tags

DTIC Thesaurus Topics

  • Amplitude
  • Chlorides
  • Differential Equations
  • Electronic Mail
  • Equations
  • Experimental Data
  • Ionic Current
  • Mathematical Models
  • Membrane Potentials
  • Membranes
  • Military Research
  • Models
  • Nonlinear Systems
  • Overload
  • Simulations
  • Tissues
  • Voltage

Fields of Study

  • Biology

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