Stretch Activated ION Channels in Myocytes: Parameter Estimation, Simulations and Phenomena

Abstract

Mechanosensitive ion channels influence the electrophysiological state of cardiac myocytes. An examination of the mechanisms of mechano-electrical coupling on cellular level by the mechanosensitive ion channels was performed. Simulations with a detailed electrophysiological model were carried out. Static stretch leaded to an increase of the resting potential and a decrease of the duration of the action potential with increasing sarcomere length. Dynamic stretch delivered a variety of phenomena depending on the duration and amplitude of the stretch. An arrhythmogenic single cell phenomenon, early afterdepolarisation, was observed.

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Document Details

Document Type
Technical Report
Publication Date
Oct 25, 2001
Accession Number
ADA409903

Entities

People

  • C. D. Werner
  • C. Riedel
  • F. B. Sachse
  • G. Seemann

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  • Counter WMD

DTIC Thesaurus Topics

  • Abstracts
  • Amplitude
  • Availability
  • Classification
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  • Couplings
  • Engineering
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  • Monitoring
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  • Biology
  • Medicine

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