Comparison of the Transdermal Ballistic Delivery of Micro-Particles into Human and Porcine Skin

Abstract

This paper describes a comparative investigation into the impact penetration characteristics of DNA-coated gold micro-particles into human and porcine skin. This work is aimed at establishing the link between the particle parameters required in delivering particles to the epidermis of pigs and humans. The particles are delivered to the skin using the PowderJect concept: a method that accelerates vaccines and drugs in micro-particle form to velocities sufficient to penetrate the skin and achieve a therapeutic effect. Devices are configured to deliver particles to predetermined velocities to both the in-vivo inguinal region of the pig and the ex-vivo skin from the human back and arm. Location of the gold particles within the tissue sites was assayed in histological sections taken from the tissue sites. The penetration results in pig and human tissue are analyzed and compared with calculations performed with a semi-empirical unified penetration model.

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Document Details

Document Type
Technical Report
Publication Date
Oct 25, 2001
Accession Number
ADA410062

Entities

People

  • B. J. Bellhouse
  • F. V. Carter
  • M. A. Kendall
  • Tom Mitchell

Organizations

  • University of Oxford

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Alkanes
  • Clinical Trials
  • Digital Cameras
  • Epidermis
  • Experimental Data
  • High Density
  • Histological Techniques
  • Mechanical Properties
  • Models
  • Mucous Membrane
  • Particles
  • Shock Tubes
  • Skin
  • Strain Rate
  • Thickness
  • Tissues

Readers

  • Computational Fluid Dynamics (CFD)
  • Toxicology/Environmental Toxicology
  • Trauma Surgery or Emergency Medicine.

Technology Areas

  • Biotechnology